Breakthrough Technologies

Gut microbiome in Health and Disease

We are 30 trillion human cells and 100 trillion microbial cells. These microbial communities play critical roles in supporting life and health. The microbiome is the collective genome of organisms that live in, on and around us, sometimes referred to as the forgotten organ. It plays a key role in health and disease. Dysbiosis is both a cause as well as an indicator of disease.

The new paradigm in medicine: microbiome therapeutics

The microbiome acts as master regulator of the immune system. The gut microbiota plays a fundamental role in local and systemic immunity and homeostasis. The host-microbe interaction leads to fine-tuned regulation of innate and adaptive immune repsonses. The modulation of the severity of a disorder through dietary interventions and their influence on microbiome–immune interactions is an exciting area of research.

microbiome targeted therapeutics immunology IBD neurology rheumatology

MRM Health’s breakthrough Technologies

We develop Optimized Consortia, the next-generation of microbiome therapeutics based on live bacterial consortia. Using a bioinformatics-guided in-human discovery engine and our Microbiome Optimization Technology, disease-specific therapeutic consortia are designed with optimized potency, capable of effective engraftment and rapid onset-of-action, with a range of robust and superior functional responses. Our unique consortium manufacturing technology as single Drug Substance allows scalable and accelerated manufacturing development with strongly reduced complexity and Cost of Goods.

Patient-driven strain selection

Our patient-driven bioinformatics platform paired with disease mechanism screening and the SHIME® gut simulator allows enhanced microbial strain selection.

Proprietary Consortia Optimization

Our proprietary optimization platform bolsters our consortia’s efficacy by enhancing strain robustness and creating synergistic, supportive ecosystems.

Enhanced Engraftment

Optimization primes consortia for successful in situ activity and efficient engraftment in the GI tract, driving therapeutic efficacy.

cGMP-compliant Manufacturing

Our unique single-step consortia manufacturing process offers excellent scalability, standardization, and regulatory advantages as a “single drug substance.

Our Next-generation Microbiome Therapeutics

MRM Health is well positioned to demonstrate superior clinical success with rational strain selection, potency- and efficacy-driving optimization, and excellent manufacturability

Our technology - SHIME®
Simulator of the Human Intestinal Microbial Ecosystem

  • Most advanced simulator of the human gut on the market
  • Allows to model the complete intestine in the lab
  • Direct insight into intestinal processes
  • Complete intestinal microbiome in natural environment
  • Modeling of intake and digestion of food and pharmaceuticals
  • Simulator of the Human Intestinal Microbial Ecosystem
    Microbiome therapeutics technology research in novel medicines

    Microbiome specialists

    Unique and differentiating platform for the discovery and development of novel microbiome-based therapeutics to overcome critical bottlenecks currently hampering microbiome-based product development.

    Based on over a decade of experience in microbiome research and development.

    Integrated in MRM Technologies Center of Excellence for Microbiome R&D (+/- 2.000m² dedicated facilities).

    End-to-end development capabilities, from discovery to CMC, regulatory and clinical development.

    Current team: 25 FTEs and hiring, with seasoned management and specialist R&D team.

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